In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins

ABSTRACT Coronavirus (CoV) replication and transcription are carried out in close proximity to restructured endoplasmic reticulum (ER) membranes in replication/transcription complexes (RTC).Many of the CoV nonstructural proteins (nsps) are required for RTC function; however, not all of their functions are known.nsp15 contains an endoribonuclease do

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The role of domestic animals in the epidemiology of human african trypanosomiasis in Ngorongoro conservation area, Tanzania

Abstract Background Trypanosomiasis is a neglected tropical disease caused by the trypanosome parasite and transmitted by the tsetse fly vector.In Sub-saharan Africa, both the human and animal variants of the disease are a great obstacle towards agriculture, development, and health.In order to better understand and therefore combat Trypanosomiasis,

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